Peer-reviewed publications

2019

45. Bottieau E, Mukendi D, Kalo JL, Lutumba P, Barbé B, Ramadan K, Van Esbroeck M, Jacobs J, Yansouni CP, Chappuis F, Boelaert M, Winkler AS, Verdonck K. Potential usefulness of C-reactive protein and procalcitonin determination in patients admitted for neurological disorders in rural Democratic Republic of Congo. Sci Rep. 2019 Oct 29;9(1):15505. doi: 10.1038/s41598-019-51925-z. PubMed PMID: 31664120; PubMed Central PMCID: PMC6820716.

44. Bremer Hinckel BC, Marlais T, Airs S, Bhattacharyya T, Imamura H, Dujardin JC, El-Safi S, Singh OP, Sundar S, Falconar AK, Andersson B, Litvinov S, Miles MA, Mertens P. Refining wet lab experiments with in silico searches: A rational quest for diagnostic peptides in visceral leishmaniasis. PLoS Negl Trop Dis. 2019 May 6;13(5):e0007353. doi: 10.1371/journal.pntd.0007353. eCollection 2019 May. PubMed PMID: 31059497; PubMed Central PMCID: PMC6522066.

43. Mollett G, Bremer Hinckel BC, Bhattacharyya T, Marlais T, Singh OP, Mertens P, Falconar AK, El-Safi S, Sundar S, Miles MA. Detection of Immunoglobulin G1 Against rK39 Improves Monitoring of Treatment Outcomes in Visceral Leishmaniasis. Clin Infect Dis. 2019 Sep 13;69(7):1130-1135. doi: 10.1093/cid/ciy1062. PubMed PMID: 30541022; PubMed Central PMCID: PMC6743847.

2018

42. Boelaert M, Mukendi D, Bottieau E, Kalo Lilo JR, Verdonck K, Minikulu L, Barbé B, Gillet P, Yansouni CP, Chappuis F, Lutumba P. A Phase III Diagnostic Accuracy Study of a Rapid Diagnostic Test for Diagnosis of Second-Stage Human African Trypanosomiasis in the Democratic Republic of the Congo. EBioMedicine. 2018 Jan;27:11-17. doi: 10.1016/j.ebiom.2017.10.032. Epub 2017 Dec 6. PubMed PMID: 29246478; PubMed Central PMCID: PMC5828295.

41. El Safi S, Elshikh H, El Sanousi E, El Amin N, Mohammed A, Verdonck K, Jacobs J, Boelaert M, Chappuis F. Case Report: Visceral Leishmaniasis with Salmonella Paratyphi and Brucella melitensis Coinfection as a Cause of Persistent Fever in a Patient from Sudan. Am J Trop Med Hyg. 2018 Nov;99(5):1150-1152. doi: 10.4269/ajtmh.18-0466. PubMed PMID: 30255832; PubMed Central PMCID: PMC6221239.

40. Koirala KD, Chappuis F, Verdonck K, Rijal S, Boelaert M. Persistent febrile illnesses in Nepal: A systematic review. Indian J Med Res. 2018 Oct;148(4):385-395. doi: 10.4103/ijmr.IJMR_505_18. PubMed PMID: 30666001; PubMed Central PMCID: PMC6362719.

39. Kristanti H, Meyanti F, Wijayanti MA, Mahendradhata Y, Polman K, Chappuis F, Utzinger J, Becker SL, Murhandarwati EEH. Diagnostic comparison of Baermann funnel, Koga agar plate culture and polymerase chain reaction for detection of human Strongyloides stercoralis infection in Maluku, Indonesia. Parasitol Res. 2018 Oct;117(10):3229-3235. doi: 10.1007/s00436-018-6021-5. Epub 2018 Aug 3. PubMed PMID: 30074085.

38. Marlais T, Bhattacharyya T, Singh OP, Mertens P, Gilleman Q, Thunissen C, Hinckel BCB, Pearson C, Gardner BL, Airs S, de la Roche M, Hayes K, Hafezi H, Falconar AK, Eisa O, Saad A, Khanal B, Bhattarai NR, Rijal S, Boelaert M, El-Safi S, Sundar S, Miles MA. Visceral Leishmaniasis IgG1 Rapid Monitoring of Cure vs. Relapse, and Potential for Diagnosis of Post Kala-Azar Dermal Leishmaniasis. Front Cell Infect Microbiol. 2018 Dec 13;8:427. doi: 10.3389/fcimb.2018.00427. eCollection 2018. PubMed PMID: 30619774. PubMed Central PMCID: PMC6300496.

37. Mukendi D, Kalo JL, Kayembe T, Lutumba P, Barbé B, Gillet P, Jacobs J, Yansouni CP, Chappuis F, Verdonck K, Boelaert M, Winkler AS, Bottieau E. Where there is no brain imaging: Safety and diagnostic value of lumbar puncture in patients with neurological disorders in a rural hospital of Central Africa. J Neurol Sci. 2018 Oct 15;393:72-79. doi: 10.1016/j.jns.2018.08.004. Epub 2018 Aug 9. PubMed PMID: 30121441.

2017

36. Bhattacharyya T, Marlais T, Miles MA. Diagnostic antigens for visceral leishmaniasis: clarification of nomenclatures. Parasit Vectors. 2017 Apr 13;10(1):178. doi: 10.1186/s13071-017-2120-x. Review. PubMed PMID: 28407812; PubMed Central PMCID: PMC5390433.

35. Mukendi D, Lilo Kalo JR, Mpanya A, Minikulu L, Kayembe T, Lutumba P, Barbé B, Gillet P, Jacobs J, Van Loen H, Yansouni CP, Chappuis F, Ravinetto R, Verdonck K, Boelaert M, Winkler AS, Bottieau E. Clinical Spectrum, Etiology, and Outcome of Neurological Disorders in the Rural Hospital of Mosango, the Democratic Republic of Congo. Am J Trop Med Hyg. 2017 Nov;97(5):1454-1460. doi: 10.4269/ajtmh.17-0375. Epub 2017 Aug 18. PubMed PMID: 28820708; PubMed Central PMCID: PMC5817781.

34. Rai K, Bhattarai NR, Vanaerschot M, Imamura H, Gebru G, Khanal B, Rijal S, Boelaert M, Pal C, Karki P, Dujardin JC, Van der Auwera G. Single locus genotyping to track Leishmania donovani in the Indian subcontinent: Application in Nepal. PLoS Negl Trop Dis. 2017 Mar 1;11(3):e0005420. doi: 10.1371/journal.pntd.0005420. eCollection 2017 Mar. PubMed PMID: 28249021; PubMed Central PMCID: PMC5348045.

2016

33. Alirol E, Horie NS, Barbé B, Lejon V, Verdonck K, Gillet P, Jacobs J, Büscher P, Kanal B, Bhattarai NR, El Safi S, Phe T, Lim K, Leng L, Lutumba P, Mukendi D, Bottieau E, Boelaert M, Rijal S, Chappuis F. Diagnosis of Persistent Fever in the Tropics: Set of Standard Operating Procedures Used in the NIDIAG Febrile Syndrome Study. PLoS Negl Trop Dis. 2016 Nov 3;10(11):e0004749. doi: 10.1371/journal.pntd.0004749. eCollection 2016 Nov. PubMed PMID: 27812090; PubMed Central PMCID: PMC5094701.

32. Barbé B, Verdonck K, El-Safi S, Khanal B, Teav S, Lilo Kalo JR, Ravinetto R, Chappuis F, Boelaert M, Jacobs J. Rapid Diagnostic Tests for Neglected Infectious Diseases: Case Study Highlights Need for Customer Awareness and Postmarket Surveillance. PLoS Negl Trop Dis. 2016 Nov 3;10(11):e0004655. doi: 10.1371/journal.pntd.0004655. eCollection 2016 Nov. PubMed PMID: 27812099; PubMed Central PMCID: PMC5094593.

31. Barbé B, Verdonck K, Mukendi D, Lejon V, Lilo Kalo JR, Alirol E, Gillet P, Horié N, Ravinetto R, Bottieau E, Yansouni C, Winkler AS, van Loen H, Boelaert M, Lutumba P, Jacobs J. The Art of Writing and Implementing Standard Operating Procedures (SOPs) for Laboratories in Low-Resource Settings: Review of Guidelines and Best Practices. PLoS Negl Trop Dis. 2016 Nov 3;10(11):e0005053. doi: 10.1371/journal.pntd.0005053. eCollection 2016 Nov. Review. PubMed PMID: 27812100; PubMed Central PMCID: PMC5094690.

30. Becker SL, Yap P, Horié NS, Alirol E, Barbé B, Bhatta NK, Bhattarai NR, Bottieau E, Chatigre JK, Coulibaly JT, Fofana HK, Jacobs J, Karki P, Khanal B, Knopp S, Koirala K, Mahendradhata Y, Mertens P, Meyanti F, Murhandarwati EH, N’Goran EK, Peeling RW, Pradhan B, Ravinetto R, Rijal S, Sacko M, Saye R, Schneeberger PH, Schurmans C, Silué KD, Steinmann P, van Loen H, Verdonck K, van Lieshout L, von Müller L, Yao JA, Boelaert M, Chappuis F, Polman K, Utzinger J. Experiences and Lessons from a Multicountry NIDIAG Study on Persistent Digestive Disorders in the Tropics. PLoS Negl Trop Dis. 2016 Nov 3;10(11):e0004818. doi: 10.1371/journal.pntd.0004818. eCollection 2016 Nov. PubMed PMID: 27812101; PubMed Central PMCID: PMC5094778.

29. Boelaert M; NIDIAG Consortium. Clinical Research on Neglected Tropical Diseases: Challenges and Solutions. PLoS Negl Trop Dis. 2016 Nov 3;10(11):e0004853. doi: 10.1371/journal.pntd.0004853. eCollection 2016 Nov. PubMed PMID: 27812095; PubMed Central PMCID: PMC5094657.

28. El-Safi S, Chappuis F, Boelaert M. The Challenges of Conducting Clinical Research on Neglected Tropical Diseases in Remote Endemic Areas in Sudan. PLoS Negl Trop Dis. 2016 Nov 3;10(11):e0004736. doi: 10.1371/journal.pntd.0004736. eCollection 2016 Nov. PubMed PMID: 27812094; PubMed Central PMCID: PMC5094669.

27. Ravinetto R, Alirol E, Mahendradhata Y, Rijal S, Lutumba P, Sacko M, El-Safi S, Lim K, van Loen H, Jacobs J, Peeling RW, Chappuis F, Boelaert M. Clinical Research in Neglected Tropical Diseases: The Challenge of Implementing Good Clinical (Laboratory) Practices. PLoS Negl Trop Dis. 2016 Nov 3;10(11):e0004654. doi: 10.1371/journal.pntd.0004654. eCollection 2016 Nov. PubMed PMID: 27812089; PubMed Central PMCID: PMC5094655.

26. Ravinetto R, Becker SL, Sacko M, El-Safi S, Mahendradhata Y, Lutumba P, Rijal S, Lim K, Sundar S, N’Goran EK, Verdonck K, Utzinger J, Chappuis F, Boelaert M. Governance and Standards in International Clinical Research: The Role of Transnational Consortia. Am J Bioeth. 2016 Oct;16(10):59-61. doi: 10.1080/15265161.2016.1214317. PubMed PMID: 27653405.

25. Schneeberger PHH, Becker SL, Pothier JF, Duffy B, N’Goran EK, Beuret C, Frey JE, Utzinger J. Metagenomic diagnostics for the simultaneous detection of multiple pathogens in human stool specimens from Côte d’Ivoire: a proof-of-concept study. Infect Genet Evol. 2016 Jun;40:389-397. doi: 10.1016/j.meegid.2015.08.044. Epub 2015 Sep 25. PubMed PMID: 26391184.

2015

24. Becker SL, Chatigre JK, Coulibaly JT, Mertens P, Bonfoh B, Herrmann M, Kuijper EJ, N’Goran EK, Utzinger J, von Müller L. Molecular and culture-based diagnosis of Clostridium difficile isolates from Côte d’Ivoire after prolonged storage at disrupted cold chain conditions. Trans R Soc Trop Med Hyg. 2015 Oct;109(10):660-8. doi: 10.1093/trstmh/trv071. Epub 2015 Sep 8. PubMed PMID: 26354793.

23. Becker SL, Piraisoody N, Kramme S, Marti H, Silué KD, Panning M, Nickel B, Kern WV, Herrmann M, Hatz CF, N’Goran EK, Utzinger J, von Müller L. Real-time PCR for detection of Strongyloides stercoralis in human stool samples from Côte d’Ivoire: diagnostic accuracy, inter-laboratory comparison and patterns of hookworm co-infection. Acta Trop. 2015 Oct;150:210-7. doi: 10.1016/j.actatropica.2015.07.019. Epub 2015 Jul 26. PubMed PMID: 26215130.

22. Becker SL, Chappuis F, Polman K, N’Goran EK, von Müller L, Utzinger J. Reply: Epidemiologic studies need asymptomatic controls. Clin Microbiol Infect. 2015 Aug;21(8):e53-4. doi: 10.1016/j.cmi.2015.04.024. Epub 2015 May 8. PubMed PMID: 25964150.

21. Becker SL, Chatigre JK, Gohou JP, Coulibaly JT, Leuppi R, Polman K, Chappuis F, Mertens P, Herrmann M, N’Goran EK, Utzinger J, von Müller L. Combined stool-based multiplex PCR and microscopy for enhanced pathogen detection in patients with persistent diarrhoea and asymptomatic controls from Côte d’Ivoire. Clin Microbiol Infect. 2015 Jun;21(6):591.e1-10. doi: 10.1016/j.cmi.2015.02.016. Epub 2015 Mar 3. PubMed PMID: 25743578.

20. Polman K, Becker SL, Alirol E, Bhatta NK, Bhattarai NR, Bottieau E, Bratschi MW, Burza S, Coulibaly JT, Doumbia MN, Horié NS, Jacobs J, Khanal B, Landouré A, Mahendradhata Y, Meheus F, Mertens P, Meyanti F, Murhandarwati EH, N’Goran EK, Peeling RW, Ravinetto R, Rijal S, Sacko M, Saye R, Schneeberger PH, Schurmans C, Silué KD, Thobari JA, Traoré MS, van Lieshout L, van Loen H, Verdonck K, von Müller L, Yansouni CP, Yao JA, Yao PK, Yap P, Boelaert M, Chappuis F, Utzinger J. Erratum to: Diagnosis of neglected tropical diseases among patients with persistent digestive disorders (diarrhoea and/or abdominal pain ≥14 days): a multi-country, prospective, non-experimental case-control study. BMC Infect Dis. 2015 Nov 4;15:499. doi: 10.1186/s12879-015-1160-0. PubMed PMID: 26537896; PubMed Central PMCID: PMC4634142.

19. Utzinger J, Becker SL, van Lieshout L, van Dam GJ, Knopp S. New diagnostic tools in schistosomiasis. Clin Microbiol Infect. 2015 Jun;21(6):529-42. doi: 10.1016/j.cmi.2015.03.014. Epub 2015 Apr 3. Review. PubMed PMID: 25843503.

2014

18. Bhattacharyya T, Ayandeh A, Falconar AK, Sundar S, El-Safi S, Gripenberg MA,Bowes DE, Thunissen C, Singh OP, Kumar R, Ahmed O, Eisa O, Saad A, Silva Pereira S, Boelaert M, Mertens P, Miles MA. IgG1 as a potential biomarker of post-chemotherapeutic relapse in visceral leishmaniasis, and adaptation to a rapid diagnostic test. PLoS Negl Trop Dis. 2014 Oct 23;8(10):e3273. doi: 10.1371/journal.pntd.0003273. eCollection 2014 Oct. PubMed PMID: 25340782; PubMed Central PMCID: PMC4207679.

17. Bhattacharyya T, Bowes DE, El-Safi S, Sundar S, Falconar AK, Singh OP, Kumar R, Ahmed O, Boelaert M, Miles MA. Significantly lower anti-Leishmania IgG responses in Sudanese versus Indian visceral leishmaniasis. PLoS Negl Trop Dis. 2014 Feb 20;8(2):e2675. doi: 10.1371/journal.pntd.0002675. eCollection 2014 Feb. PubMed PMID: 24587456; PubMed Central PMCID: PMC3930516.

16. Bottieau E, Mukendi D, Kalo JR, Mpanya A, Lutumba P, Barbé B, Chappuis F, Lunguya O, Boelaert M, Jacobs J. Fatal Chromobacterium violaceum bacteraemia in rural Bandundu, Democratic Republic of the Congo. New Microbes New Infect. 2014 Nov 12;3:21-3. doi: 10.1016/j.nmni.2014.10.007. eCollection 2015 Jan. PubMed PMID: 25755887; PubMed Central PMCID: PMC4337932.

15. Büscher P, Mertens P, Leclipteux T, Gilleman Q, Jacquet D, Mumba-Ngoyi D, Pyana PP, Boelaert M, Lejon V. Sensitivity and specificity of HAT Sero-K-SeT, a rapid diagnostic test for serodiagnosis of sleeping sickness caused by Trypanosoma brucei gambiense: a case-control study. Lancet Glob Health. 2014 Jun;2(6):e359-63. doi: 10.1016/S2214-109X(14)70203-7. Epub 2014 May 9. PubMed PMID: 25103304.

14. Mpanya A, Boelaert M, Baloji S, Matangila J, Lubanza S, Bottieau E, Chappuis F, Lutumba P, Hendrickx D. Diagnostic work-up of neurological syndromes in a rural African setting: knowledge, attitudes and practices of health care providers. PLoS One. 2014 Oct 23;9(10):e110167. doi:

10.1371/journal.pone.0110167. eCollection 2014. PubMed PMID: 25340726; PubMed Central PMCID: PMC4207747.

13. Rogé S, Van Nieuwenhove L, Meul M, Heykers A, Brouwer de Koning A, Bebronne N, Guisez Y, Büscher P. Recombinant antigens expressed in Pichia pastoris for the diagnosis of sleeping sickness caused by Trypanosoma brucei gambiense. PLoS Negl Trop Dis. 2014 Jul 17;8(7):e3006. doi: 10.1371/journal.pntd.0003006. eCollection 2014 Jul. PubMed PMID: 25032684; PubMed Central PMCID: PMC4102443.

2013

12. Bhattacharyya T, Boelaert M, Miles MA. Comparison of visceral leishmaniasis diagnostic antigens in African and Asian Leishmania donovani reveals extensive diversity and region-specific polymorphisms. PLoS Negl Trop Dis. 2013;7(2):e2057. doi: 10.1371/journal.pntd.0002057. Epub 2013 Feb 28. PubMed PMID: 23469296; PubMed Central PMCID: PMC3585016.

11. Becker SL, Vogt J, Knopp S, Panning M, Warhurst DC, Polman K, Marti H, von Müller L, Yansouni CP, Jacobs J, Bottieau E, Sacko M, Rijal S, Meyanti F, Miles MA, Boelaert M, Lutumba P, van Lieshout L, N’Goran EK, Chappuis F, Utzinger J. Persistent digestive disorders in the tropics: causative infectious pathogens and reference diagnostic tests. BMC Infect Dis. 2013 Jan 24;13:37. doi: 10.1186/1471-2334-13-37. Review. PubMed PMID: 23347408; PubMed Central PMCID: PMC3579720.

10. Bottieau E. Point-of-care testing: filling the diagnostic gaps in tropical medicine? Clin Microbiol Infect. 2013 May;19(5):397-8. doi: 10.1111/1469-0691.12200. PubMed PMID: 23574550.

9. Büscher P, Gilleman Q, Lejon V. Rapid diagnostic test for sleeping sickness. N Engl J Med. 2013 Mar 14;368(11):1069-70. doi: 10.1056/NEJMc1210373. PubMed PMID: 23484849.

8. Chappuis F, Alirol E, d’Acremont V, Bottieau E, Yansouni CP. Rapid diagnostic tests for non-malarial febrile illness in the tropics. Clin Microbiol Infect. 2013 May;19(5):422-31. doi: 10.1111/1469-0691.12154. Epub 2013 Feb 15. Review. PubMed PMID: 23413992.

7. Fürst T, Silué KD, Ouattara M, Adiossan LG, N’Goran DN, Yao AJ, Koné S, N’Goran EK, Utzinger J, Bogoch II. Patients routinely report more symptoms to experienced field enumerators than physicians in rural Cote d’Ivoire. Am J Trop Med Hyg. 2013 Sep;89(3):592-6. doi: 10.4269/ajtmh.13-0122. Epub 2013 Jul 22. PubMed PMID: 23878181; PubMed Central PMCID: PMC3771305.

6. Knopp S, Becker SL, Ingram KJ, Keiser J, Utzinger J. Diagnosis and treatment of schistosomiasis in children in the era of intensified control. Expert Rev Anti Infect Ther. 2013 Nov;11(11):1237-58. doi: 10.1586/14787210.2013.844066. Epub 2013 Oct 16. Review. PubMed PMID: 24127662.

5. Meheus F, Abuzaid AA, Baltussen R, Younis BM, Balasegaram M, Khalil EAG, Boelaert M, Musa AM. The economic burden of visceral leishmaniasis in Sudan: an assessment of provider and household costs. Am J Trop Med Hyg. 2013 Dec;89(6):1146-1153. doi: 10.4269/ajtmh.12-0585. Epub 2013 Nov 4. PubMed PMID: 24189368; PubMed Central PMCID: PMC3854893.

4. Uranw S, Meheus F, Baltussen R, Rijal S, Boelaert M. The household costs of visceral leishmaniasis care in south-eastern Nepal. PLoS Negl Trop Dis. 2013;7(2):e2062. doi: 10.1371/journal.pntd.0002062. Epub 2013 Feb 28. PubMed PMID: 23469298; PubMed Central PMCID: PMC3585119.

3. Yansouni CP, Bottieau E, Lutumba P, Winkler AS, Lynen L, Büscher P, Jacobs J, Gillet P, Lejon V, Alirol E, Polman K, Utzinger J, Miles MA, Peeling RW, Muyembe JJ, Chappuis F, Boelaert M. Rapid diagnostic tests for neurological infections in central Africa. Lancet Infect Dis. 2013 Jun;13(6):546-58. doi: 10.1016/S1473-3099(13)70004-5. Epub 2013 Apr 24. Review. PubMed PMID: 23623369.

2012

2. Utzinger J, Becker SL, Knopp S, Blum J, Neumayr AL, Keiser J, Hatz CF. Neglected tropical diseases: diagnosis, clinical management, treatment and control. Swiss Med Wkly. 2012 Nov 22;142:w13727. doi: 10.4414/smw.2012.13727. eCollection 2012. Review. PubMed PMID: 23180107.

1. Yansouni CP, Bottieau E, Chappuis F, Phoba MF, Lunguya O, Ifeka BB, Jacobs J. Rapid diagnostic tests for a coordinated approach to fever syndromes in low-resource settings. Clin Infect Dis. 2012 Aug;55(4):610-1; author reply 611-2. doi: 10.1093/cid/cis466. Epub 2012 May 4. PubMed PMID: 22563019.

Other publications and press releases

Ethics charter & Good clinical practices

NIDIAG Ethics charter is available here.

A collection of NIDIAG papers on Good Clinical Practices is available here: https://collections.plos.org/ntdsgoodclinicalpractice

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